首页> 外文期刊>Clinical and vaccine immunology: CVI >Unique Th1/Th2 phenotypes induced during priming and memory phases by use of interleukin-12 (IL-12) or IL-28B vaccine adjuvants in rhesus macaques.
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Unique Th1/Th2 phenotypes induced during priming and memory phases by use of interleukin-12 (IL-12) or IL-28B vaccine adjuvants in rhesus macaques.

机译:独特的Th1 / Th2表型诱导期间启动利用interleukin-12和记忆阶段在恒河(il - 12)或IL-28B疫苗佐剂猕猴。

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摘要

Adjuvant compounds are usually included in vaccinations in order to bolster total vaccine-specific responses or to tailor an immune response toward a desired endpoint, such as the production of gamma interferon or an increase in antibody titers. While most adjuvants are studied in regard to their impact on vaccine-specific responses during and just after the vaccination period, a detailed analysis of how adjuvants skew the Th1/Th2 axis at more distant time points is not often undertaken. In the current study, we present data that suggests that adjuvants differ in their relative abilities to bolster and skew immune responses in the short term compared with more distant time points. To that end, we have employed interleukin-12 (IL-12) and IL-28B as adjuvants for DNA vaccination of rhesus macaques. While both adjuvants were able to bolster Th1-biased responses, our analysis shows that this skewing was achieved through different mechanisms. Moreover, analysis 3 months after the final immunization revealed the activity of the IL-12 adjuvant to be short lived, while the IL-28B adjuvant continued to exert its influence on the immune system. Taken together, these data suggest that the scientific and medical communities would benefit from a more detailed analysis of adjuvant function, including the determination of long-term influences of administered adjuvants.
机译:辅助化合物通常包含在接种疫苗,以提高总特定疫苗反应或裁缝免疫反应所需的端点,等γ干扰素的生产或增加抗体滴度。关于他们对特定疫苗的影响在疫苗接种后没反应期间,详细分析佐剂倾斜Th1 / Th2轴在更遥远的时间点不经常进行。目前的数据表明,佐剂是不同的在他们的相对能力支持和倾斜免疫反应在短期内与之相比更遥远的时间点。采用interleukin-12 (il - 12)和IL-28BDNA疫苗的佐剂恒河猴。虽然佐剂能够支撑Th1-biased反应,我们的分析表明,通过不同的偏差机制。最后免疫显示的活动白介素佐剂是短暂的,而IL-28B佐剂继续发挥其影响力在免疫系统。表明,科学和医学社区将受益于一个更详细的辅助函数的分析,包括确定长期的影响管理的佐剂。

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