Study Data from Kanazawa University Graduate School of Medical Sciences Provide New Insights into Cerebral Amyloid Angiopathy (Exogenous Ab seeds induce Ab depositions in the blood vessels rather than the brain parenchyma, independently of Ab ...)

摘要

2021 SEP 23 (NewsRx) - By a News Reporter-Staff News Editor at Disease Prevention Daily - Fresh data on cerebral amyloid angiopathy are presented in a new report. According to news originating from Kanazawa University Graduate School of Medical Sciences by NewsRx correspondents, research stated, "Little is known about the effects of parenchymal or vascular amyloid b peptide (Ab) deposition in the brain. We hypothesized that Ab strain-specific information defines whether Ab deposits on the brain parenchyma or blood vessels." Financial supporters for this research include Japan Society for the Promotion of Science; Takeda Science Foundation. The news journalists obtained a quote from the research from Kanazawa University Graduate School of Medical Sciences: "We investigated 12 autopsied patients with different severities of Ab plaques and cerebral amyloid angiopathy (CAA), and performed a seeding study using an Alzheimer's disease (AD) mouse model in which brain homogenates derived from the autopsied patients were injected intracerebrally Based on the predominant pathological features, we classified the autopsied patients into four groups: AD, CAA, AD + CAA, and less Ab. One year after the injection, the pathological and biochemical features of Ab in the autopsied human brains were not preserved in the human brain extract-injected mice.