National Cancer Institute (NCI) Researchers Yield New Study Findings on Genetics (Common Threads: Aphidicolin-lnducible and Folate-Sensitive Fragile Sites in the Human Genome)

摘要

2021 SEP 21 (NewsRx) - By a News Reporter-Staff News Editor at Disease Prevention Daily - Current study results on genetics have been published. According to news originating from Bethesda, Maryland, by NewsRx correspondents, research stated, "The human genome has many chromosomal regions that are fragile, demonstrating chromatin breaks, gaps, or constrictions on exposure to replication stress. Common fragile sites (CFSs) are found widely distributed in the population, with the largest subset of these sites being induced by aphidicolin (APH)." The news journalists obtained a quote from the research from National Cancer Institute (NCI): "Other fragile sites are only found in a subset of the population. One group of these so-called rare fragile sites (RFSs) is induced by folate stress. APH-inducible CFSs are generally located in large transcriptionally active genes that are A + T rich and often enriched for tracts of AT-dinucleotide repeats. In contrast, all the folate-sensitive sites mapped to date consist of transcriptionally silenced CGG microsatellites.