New Liver Metastasis Study Findings Recently Were Reported by Researchers at Shandong University (Hyperglycemia Promotes Liver Metastasis of Colorectal Cancer Via Upregulation of Integrin Alpha V Beta 6)

摘要

2021 SEP 21 (NewsRx) - By a News Reporter-Staff News Editor at Disease Prevention Daily - A new study on Oncology - Liver Metastasis is now available. According to news originating from Shandong, People's Republic of China, by NewsRx correspondents, research stated, "Diabetes is related to higher risk of multiple cancers. This study aimed to explore the effect and mechanism of diabetes on liver metastasis of CRC." Financial support for this research came from National Natural Science Foundation of China (NSFC). Our news journalists obtained a quote from the research from Shandong University, "Overall and liver metastasis-free survival in diabetic and non-diabetic CRC patients were compared by Kaplan Meier analysis. Expression of avl36 was detected by immunohistochemistry in clinical specimens. Effects of hyperglycemia on avl36 expression in colon cancer cells were assessed by western blot, real-time PCR, and flowcytometry Effects of hyperglycemia on migration and invasion were demonstrated by Transwell assay. Expression and activity of MMP-9 and MMP-2 were determined by real-time PCR and gelatin zymography Liver metastatic nodules were counted and 136 expression was detected by western blot in a liver metastasis mouse model. CRC patients with diabetes had poorer overall and liver metastasis-free survival, and diabetes was associated with higher avl36 expression in CRC specimens. Hyperglycemia promoted the invasion and migration of colon cancer cells, and upregulated the expression and activity of MMP-9, which were attenuated by inhibition of avl36. Hyperglycemia upregulated the expression of 136 and cell surface expression of avl36, which was reduced by ERK inhibitor. The in vitro results were confirmed in vivo in the mouse model."