Qingdao University Researchers Update Current Study Findings on Dementia (Association of cerebral microbleeds with risks of cognitive impairment and dementia: A systematic review and meta-analysis of prospective studies)

摘要

2021 SEP 21 (NewsRx) - By a News Reporter-Staff News Editor at Disease Prevention Daily - Current study results on dementia have been published. According to news reporting originating from Qingdao, People's Republic of China, by NewsRx correspondents, research stated, "Cognitive impairment and dementia is a universal phenomenon in the older. And as a feature of cerebral small vessel disease (CSVD), cerebral microbleed (CMB) plays a role in the process of cognitive decline." Funders for this research include Shanghai Municipality Science and Technology Commission. Our news correspondents obtained a quote from the research from Qingdao University: "We aim to identify the association of CMBs with risks of cognitive impairment and dementia prospectively. From database inception to Sept. 12, 2020, we systematically searched PubMed, Embase and Ovid databases to obtain relative articles which have exact values in the relationship between CMB and dementia. In primary analysis, we divided the cognitive normal subjects at baseline into dementia and mild cognitive impairment (MCI) groups as outcomes. In the dementia group, we conducted subgroup analysis according to the number and locations of CMBs. A total of 32641 articles were identified and 14 articles with 11407 participants were included. The presence of CMBs increased the risk of dementia (relative risk (RR) =1.32, 95% confidence interval (Cl) =1.00-1.72, 12=21.2%, P=0.268), as well as the risk of VaD (vascular dementia) (RR=2.41, 95%CI=1.28-4.54, 12=0%, P=0.381). Subgroup analyses showed that 2 CMBs (RR=2.27, 95%CI=1.71-3.01, 12=0%, P=0.627) and deep and/or mixed CMBs (RR=1.75, 95%CI=1.09-2.80, 12=23.3%, P=0.012) were associated with the risk of dementia."