Researchers from Shiraz University Publish Research in Cardiovascular Medicine (Role of Lipid Accumulation and Inflammation in Atherosclerosis: Focus on Molecular and Cellular Mechanisms)

摘要

2021 SEP 21 (NewsRx)- By a News Reporter-Staff News Editor at Disease Prevention Daily- Investigators discuss new findings in cardiovascular medicine. According to news reporting from Shiraz, Iran, by NewsRx journalists, research stated, "Atherosclerosis is a chronic lipid-driven and maladaptive inflammatory disease of arterial intima. It is characterized by the dysfunction of lipid homeostasis and signaling pathways that control the inflammation." Financial supporters for this research include Russian Science Foundation. The news correspondents obtained a quote from the research from Shiraz University: "This article reviews the role of inflammation and lipid accumulation, especially low-density lipoprotein (LDL), in the pathogenesis of atherosclerosis, with more emphasis on cellular mechanisms. Furthermore, this review will briefly highlight the role of medicinal plants, long non-coding RNA (IncRNA), and microRNAs in the pathophysiology, treatment, and prevention of atherosclerosis. Lipid homeostasis at various levels, including receptor-mediated uptake, synthesis, storage, metabolism, efflux, and its impairments are important for the development of atherosclerosis. The major source of cholesterol and lipid accumulation in the arterial wall is proatherogenic modified low-density lipoprotein (mLDL).