Research Conducted at Uppsala University Has Updated Our Knowl-edge about Peptide Hormones (Prevention of Hemorrhage-induced Renal Vasoconstriction and Hypoxia By Angiotensin li Type 1 Receptor Antagonism In Pigs)

摘要

2021 SEP 17 (NewsRx) - By a News Reporter-Staff News Editor at Disease Prevention Daily - Current study results on Peptide Proteins - Peptide Hormones have been published. According to news reporting from Uppsala, Sweden, by NewsRx journalists, research stated, "Angiotensin II (ANG II) is a potent vasoconstrictor and may reduce renal blood flow (RBF), causing renal hypoxia. Hypotensive hemorrhage elevates plasma ANG II levels and is associated with increased risk of acute kidney injury." Funders for this research include European Commission, Magnus Bergvall Foundation. The news correspondents obtained a quote from the research from Uppsala University, "We hypothesized that ANG II antagonism prevents renal vasoconstriction and hypoxia caused by hemorrhage. Pigs were anaesthetized, surgically prepared, and randomized to intravenous losartan (1.5 mg center dot kg-1 center dot h-1, n = 8) or an equal volume of intravenous Ringer acetate (vehicletreated, n = 8). Hemorrhage was induced by continuous aspiration of blood to reach and sustain mean arterial pressure of <50 mmHg for 30 min. Plasma ANG II levels, hemodynamics and oxygenation were assessed 60 min prehemorrhage, 30-min after the start of hemorrhage, and 60 min posthemorrhage. Erythropoietin mRNA was analyzed in cortical and medullary tissue sampled at the end of the experiment.