Researchers at Shanghai Jiao Tong University School of Medicine Report Research in Sepsis (Mitophagy coordinates the mitochon-drial unfolded protein response to attenuate inflammation-mediated myocardial injury)

摘要

2021 SEP 07 (NewsRx) - By a News Reporter-Staff News Editor at Disease Prevention Daily - Data detailed on sepsis have been presented. According to news reporting from Shanghai, People's Republic of China, by NewsRx journalists, research stated, "Mitochondrial dysfunction is a fundamental challenge in septic cardiomyopathy. Mitophagy and the mitochondrial unfolded protein response (UPRmt) are the predominant stress-responsive and protective mechanisms involved in repairing damaged mitochondria." Our news journalists obtained a quote from the research from Shanghai Jiao Tong University School of Medicine: "Although mitochondrial homeostasis requires the coordinated actions of mitophagy and UPRmt, their molecular basis and interactive actions are poorly understood in sepsis-induced myocardial injury. Our investigations showed that lipopolysaccharide (LPS)-induced sepsis contributed to cardiac dysfunction and mitochondrial damage. Although both mitophagy and UPRmt were slightly activated by LPS in cardiomyocytes, their endogenous activation failed to prevent sepsis-mediated myocardial injury. However, administration of urolithin A, an inducer of mitophagy, obviously reduced sepsis-mediated cardiac depression by normalizing mitochondrial function. Interestingly, this beneficial action was undetectable in cardiomyocyte-specific FUNDC1 knockout (FUNDC1CKO) mice.