Reports from University of Texas MD Anderson Cancer Center Add New Data to Findings in Non-Small Cell Lung Cancer (Radiation-induced Lymphopenia During Chemoradiation Therapy for Non-small Cell Lung Cancer Is Linked With Age, Lung V5, and Xrcc1 ...)

摘要

2021 MAY 07 (NewsRx) - By a News Reporter-Staff News Editor at Disease Prevention Daily - Researchers detail new data in Oncology - Non-Small Cell Lung Cancer. According to news originating from Houston, Texas, by NewsRx correspondents, research stated, "We investigated clinical and genetic factors associated with severe radiation-induced lymphopenia (RIL) in a randomized clinical trial of photon vs. proton radiation, with chemotherapy, for non-small cell lung cancer. XRCC1 rs25487 was genotyped in lymphocytes from serial peripheral blood samples." Financial support for this research came from NIH National Cancer Institute (NCI). Our news journalists obtained a quote from the research from the University of Texas MD Anderson Cancer Center, "Severe RIL was defined as absolute lymphocyte count (ALC) <0.3 x 10(9) cells/L. Univariate and multivariate analyses were used to identify independent risk factors, which were then used to group patients for risk of severe RIL. Univariate analysis of the 178 patients in this analysis showed that older age, larger tumors, higher lung V5 and mean lung dose, and higher heart V5 and mean heart dose were associated with severe RIL during treatment (P <0.05).