Researchers from Rutgers University - The State University of New Jersey Report Details of New Studies and Findings in the Area of Prostate Cancer (Dna Methylome, Transcriptome, and Prostate Cancer Prevention By Phenethyl Isothiocyanate In ...)

摘要

2021 MAY 07 (NewsRx) - By a News Reporter-Staff News Editor at Disease Prevention Daily - Researchers detail new data in Oncology - Prostate Cancer. According to news reporting originating in Piscataway, New Jersey, by NewsRx journalists, research stated, "Epigenetics/epigenomics has been shown to be involved in carcinogenesis. However, how the epigenome would be altered in the transgenic adenocarcinoma of the mouse prostate (TRAMP) cancer model and the effect of cancer chemopreventive phytochemical phenethyl isothiocyanate (PEITC) on the epigenome in TRAMP mice are not known." Financial supporters for this research include NIH National Cancer Institute (NCI), National Center for Complementary and Integrative Health. The news reporters obtained a quote from the research from the Rutgers University - The State University of New Jersey, "PEITC has been reported to reduce the risk of many cancers including prostate cancer (PCa). In this study, male TRAMP mice were fed a control diet or diet containing 0.05% PEITC from 8 weeks to 16 weeks. The tumor incidence was reduced in the PEITC diet (0/6) as compared with the control diet (6/7). RNA-sequencing (RNA-seq) analyses on nontumor and tumor prostatic tissues revealed several pathways like cell cycle/Cdc42 signaling, inflammation, and cancer-related signaling, were activated in prostate tissues of TRAMP mice but were reversed or attenuated in TRAMP mice fed with PEITC diet. DNA CpG methyl-seq analyses showed that global methylation patterns of prostate samples from TRAMP mice were hugely different from those of wild-type mice.