Findings from Second Department of Cardiology Provide New Insights into Heart Failure (Serum Sulfhydryl Groups, Malondialde-hyde, Uric Acid, and Bilirubin as Predictors of Adverse Outcome in Heart Failure Patients due to Ischemic or Nonischemic ...)

摘要

2021 MAY 07(NewsRx)-By a News Reporter-Staff News Editor at Disease Prevention Daily-Investigators discuss new findings in heart failure. According to news reporting out of the Second Department of Cardiology by NewsRx editors, research stated, "Oxidative stress plays a significant role in the pathogenesis of heart failure (HF)." Our news editors obtained a quote from the research from Second Department of Cardiology: "The aim of the study was to investigate the prognostic value of oxidation-reduction (redox) markers in patients with HF due to ischemic and nonischemic cardiomyopathy. The study included 707 patients of HF allocated into two groups depending on ethology: ischemic cardiomyopathy (ICM) (n=435) and nonischemic cardiomyopathy (nICM) (n=272), who were followed up for one year. The endpoint occurrence (mortality or heart transplantation) in a 1-year follow-up was similar in the ICM and nICM group. The predictive value of endpoint occurrence of oxidative stress biomarkers such as the serum protein sulfhydryl groups (PSH), malondialdehyde (MDA), uric acid (UA), bilirubin, and MDA/PSH ratio and other clinical and laboratory data were assessed in both groups (ICM and nICM) separately using univariate and multivariate Cox regression analyses. In multivariate analysis, the higher concentrations of UA (p=0.015, HR=1.024, 95% Cl (1.005-1.044)) and MDA (p=0.004, HR=2.202, 95% Cl (1.296-3.741)) were significantly associated with adverse prognosis in patients with ICM. Contrastingly, in patients with nICM, we observed that higher bilirubin concentration (p=0.026, HR=1.034, 95% Cl (1.004-1.064)) and MDA/PSH ratio (p=0.034, HR=3.360, 95% Cl (1.096-10.302)) were significantly associated with increased risk of death or HT."