2021 MAY 05 (NewsRx) - By a News Reporter-Staff News Editor at Disease Prevention Daily - From Washington, D.C., NewsRx journalists report that a patent application by the inventors Cameron, Donald Andrew (Kingston, CA); Petkovich, Martin (Kingston, CA); Saha, Uttam (Thornhill, CA), filed on October 29, 2020, was made available online on April 15, 2021. The patent's assignee is Queen's University at Kingston (Kingston, Canada). News editors obtained the following quote from the background information supplied by the inventors: "Vitamin A metabolism gives rise to several active forms of retinoic acid (RA) which are involved in regulating gene expression during development, regeneration, and in the growth and differentiation of epithelial tissues. RA has been linked to apoptosis (i.e., programmed cell death) in a number of cell types, and has been shown to have anti-carcinogenic and anti-tumoral properties. Early studies of retinol deficiency indicated a correlation between vitamin A depletion and a higher incidence of cancer and increased susceptibility to chemical carcinogenesis. Several animal models have been used to demonstrate the effectiveness of retinoids in suppressing carcinogenesis in a variety of tissues including skin, mammary epithelia, oral cavity, aerodigestive tract, liver, bladder and prostate.
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