University of Adelaide Researchers Discuss Research in Molecular Science [Maternal Exposure to Dibutyl Phthalate (DBP) or Diethyl-stilbestrol (DES) Leads to Long-Term Changes in Hypothalamic Gene Expression and Sexual Behavior]

摘要

2021 MAY 05 (NewsRx) - By a News Reporter-Staff News Editor at Disease Prevention Daily - Data detailed on molecular science have been presented. According to news reporting originating from Adelaide, Australia, by NewsRx correspondents, research stated, "Xenobiotic exposure during pregnancy and lactation has been linked to perinatal changes in male reproductive outcomes and other endocrine parameters." Financial supporters for this research include Australian Research Council. Our news journalists obtained a quote from the research from University of Adelaide: "This pilot study wished to assess whether brief maternal exposure of rats to xenobiotics dibutyl phthalate (DBP) or diethylstilbestrol (DES) might also cause long-term changes in hypothalamic gene expression or in reproductive behavior of the resulting offspring. Time-mated female Sprague Dawley rats were given either DBP (500 mg/kg body weight, every second day from GD14.5 to PND6), DES (125 g/kg body weight at GD14.5 and GD16.5 only), or vehicle (* * n* * = 8-12 per group) and mild endocrine disruption was confirmed by monitoring postnatal anogenital distance. Hypothalamic RNA from male and female offspring at PND10, PND24 and PND90 was analyzed by qRT-PCR for expression of aromatase, oxytocin, vasopressin, ER-alpha, ER-beta, kisspeptin, and GnRH genes.