Research from University of Michigan Has Provided New Data on Science (Maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates)

摘要

2021 MAY 03 (NewsRx) - By a News Reporter-Staff News Editor at Disease Prevention Daily - Researchers detail new data in science. According to news originating from the University of Michigan by NewsRx correspondents, research stated, "Lipidome-wide metabolites may be useful biomarkers of pregnancy outcomes. We sought to characterize maternal lipidomic signatures associated with preterm birth and neonatal anthropometric parameters." Funders for this research include National Institute of Environmental Health Sciences; NIH Office of the Director. The news correspondents obtained a quote from the research from University of Michigan: "Plasma samples were collected 24-28 weeks gestation, and lipidomic profiling was quantified using high-performance liquid chromatography tandem mass spectrometry Lipid metabolites were analyzed individually and as whole lipid classes and subgroups based on degree of hydrocarbon chain saturation. Associations were estimated using linear and logistic regression. After false discovery adjustment (q <0.15), four plasmenyl-phosphatidylethanolamines and three free fatty acids associated with increased risk for spontaneous preterm birth. Five phosphatidylinositols, two phosphatidylglycerols, and one phosphatidic acid were associated with large for gestational age neonates. The saturated plasmenyl-phosphatidylethanolamines held the association with increased risk for spontaneous preterm birth. Both the mono- and poly-unsaturated free fatty acids held the association for increased risk for spontaneous preterm birth. Mono- and poly-unsaturated phosphatidylinositols were associated with large for gestational age neonates."