Collaboration to Validate Osteogenic Cell Therapy

摘要

Plasticell and CellSpring are working together to develop tissue models using CellSprings' 3D Bloom Biopolymercell culture system seeded with hMSCs that are subsequently differentiated to bone, cartilage and brown/white fat tissue using CombiCult-derived differentiation media. 3D cultures of cells were said to resemble natural tissues more closely compared to conventional 2D cultures and have more accurate biological responses to drug treatment, offering potential for identification of promising lead compounds in all stages of drug discovery. Plasticell has used its proprietary Combinatorial Cell Culture~(TM) (CombiCult~R) platform to develop media for differentiation of human mesenchymal stem cells (hMSCs) to high quality osteocytes, chondrocytes and adipocytes (both white and brown), with a view to creating tissue models for drug screening and cell therapies.