Long term maintenance of weight loss with non-surgical interventions in obese adults: systematic review and meta-analyses of randomised controlled trials

摘要

STUDY QUESTION What is the randomised controlled evidence for the effectiveness of non-surgical weight interventions for maintenance of weight loss? SUMMARY ANSWER Behavioural interventions covering both diet and physical activity show small but significant benefits on maintenance of weight loss. Orlistat 120 mg three times daily alongside behavioural interventions significantly adds to weight loss maintenance. WHAT IS KNOWN AND WHATTHIS PAPER ADDS Behaviour change leads to moderate clinically meaningful changes in weight, but most individuals regain lost weight after initial weight loss. Behavioural interventions covering both diet and physical activity show small but significant benefits on weight loss maintenance for up to 24 months. Pharmacological support from orlistat 120 mg three times daily also shows small but significant benefits on weight loss maintenance for up to 36 months.