Antidepressant efficacy of agomelatine: meta-analysis of published and unpublished studies

摘要

Previous meta-analyses have produced varied estimates of the efficacy of agomelatine because of differences in the number and type of studies included. This analysis included all completed studies of agomelatine in the acute treatment of depression and showed modest efficacy forthe drug, albeit with some publication bias.Acute studies (6-12 weeks) evaluating the efficacy of agomelatine in the treatment of depression in adults were eligible for inclusion. Included studies were also randomised, double blind, and controlled (placebo and/or antidepressant). Patients met criteria for major depressive disorder (MDD) as defined by each study.