Eight Weeks of Exercise Training on 6MWT, Heart Function, and CHF Biomarker in Patients with Chronic Heart Failure

摘要

Abstract The aim of this study was to evaluate the effect of concurrent aerobic-resistance training (CART) on aerobic power, heart function, and biomarker in patients with chronic heart failure (CHF). A total of 76 HF with reduced ejection fraction (HFrEF) (EF < 40%) participated in the two groups, intervention group (IG, N= 38) and control group(CG, N = 38) that IG performed an 8-week CART program (3 times a week for 45-60 min) and walking (another 4 days a week for 30 min). 6MWT, heart rate variability, echocardiography parameters, NT-proBNP, and Galectin-3(Gal-3) were evaluated before and after the program. The comparison of CG and IG showed that 6MWT (277.89 ± 51.31 vs. 200.00 ± 32.33) and EF (32.89 ± 5.34vs. 32.1 ±4.53) had increased, and DIVS (10.14 ± 0.88 vs. 10.47 ± 0.76), LVEDD (52.71 ± 6.16vs. 53.71 ± 5.12), LVESD (46.71 ± 5.68vs. 47.05 ± 6.04), heart rate (80.26 ± 7.97vs. 94.71 ± 14.52), NT-proBNP, and Gal-3 levels had decreased after 8 weeks, respectively (p<0/ 05). The results showed that the CART program could improve aerobic power, heart rate, and echocardiographic parameters in CHF.