HPV vaccine safety: Cochrane launches urgent inquiry after review criticisms

摘要

A Cochrane review that gave the all-clear to vaccines designed to prevent cervical cancer did not include all the relevant trials and ignored possible sources of bias, a new analysis suggests. The review, published in May 2017, based its conclusions on 26 studies involving 73 428 women. But it could have included as many as 46 trials involving more than 120 000 women, say researchers Lars Jorgensen and Peter G0tzsche of the Nordic Cochrane Centre in Copenhagen, and Tom Jefferson of the Centre for Evidence Based Medicine in Oxford.