Vinyl Esters as Acetaldehyde Surrogates: Potential Utility in Some Common Multicomponent Sequences

摘要

Limited applicability of acetaldehyde in many multicomponent sequences widely restrict its utility in synthetic chemistry, diver- sity oriented synthesis and drug discovery efforts. Present re- port evaluates the potential scope of vinyl esters as acetalde- hyde surrogates in some common multicomponent reactions (MCRs). Reactions were quite successful with cyclic 1,3-dike- tones and methyl substituted acridione, thioxanthendione, bis (hydroxycyclohex-2-enone), tetrahydroquinazolindione de- rivatives were obtained in moderate to good yield. With sub- strates like aniline and 2-naphthol, vinyl esters simply acted as acylating agent in place of desired acetaldehyde equivalents.