Pyrrolo[2,3-b]pyridine Derivatives: Synthesis and Preliminary Evaluation of their Calf Thymus DNA Binding Properties

摘要

Benzothiazole, benzimidazole and imidazopyridine promoted substitutions at C3 position of 1H-pyrrolo[2,3-b]pyridine have been reported. A new series of acylation as well as mono- alkylation and dialkylation of 1H-pyrrolo[2,3-b]pyridine with dif- ferent acyl and alkyl halides has been synthesized in moderate to good yields. Palladium catalyzed Suzuki-Miyaura cross-cou- pling has also been approached for the arylation at C6 position of imidazopyridine. Further, interaction studies of these com- pounds have been performed with calf thymus-DNA using UV- visible and fluorescence spectroscopic techniques. The effect of ionic strength and iodide, determined by absorption and emis- sion spectra, supported the binding of compounds with ct- DNA.