Short Synthesis of Novel Recyclable Chiral Bifunctional Thioureas from Aminoalkyl Polystyrene and their use as Organocatalysts in Stereoselective aza-Henry Reaction.

摘要

A series of supported bifunctional thioureas has been prepared, in one or two steps, from commercially available aminoalkyl polystyrene resins. They differ in the length of the tether at- taching the thiourea to the polymer chain, and the nature of the amino thiourea component. All the materials are able to promote stereoselective aza-Henry reaction with very good stereoselection, and they can be recycled maintaining the cata- lytic activity.