Asymmetric Synthesis of Cyclic Nitrones via Organocatalytic Michael Addition of Aldehydes to Nitroolefins and Subsequent Reductive Cyclization.

摘要

A direct approach to the synthesis of optically active fivemembered cyclic nitrones is described. The presented strategy is based on organocatalytic Michael addition of aldehydes to trans-nitroalkenes and subsequent reductive cyclization. The developed methodology was successfully applied to the asymmetric synthesis of Methdilazine.