One-Step Synthesis of Fused Chromeno[4,3-b]pyrrolo [3,2-h]quinolin-7(1H)-One Compounds and their Anticancer Activity Evaluation

摘要

FeCl3 catalyzed synthesis of chromeno[4,3-b]pyrrolo[3,2-h]quinolin- 7(1H)-one compounds is reported in this paper. The target molecules were synthesized by combining 4-hydroxy coumarin, 7- amino indole and diverse aromatic aldehydes in 1,4-dioxane as a solvent, at 90 8C. The final compounds obtained were subjected to anticancer activity evaluation using murine melanoma cell lines (B16F10). Best result was obtained for compound bearing 2-chloro-3-pyridyl substituent, which showed IC50 value of 70.74 mM.