Metal-Free Remote C-H Bond Acetoxylation of 8-Aminoquinolines on the C5-Position

摘要

Herein, we describe a simple and practical approach for the selective acetoxylation at the C5-position of 8-aminoquinoline amides under metal free conditions. Our strategy shows high conversion efficiency, broad substrate scope, and functional group tolerance giving access to various C5-acetoxylated carboxamides, sulfonamides or phosphinamides in good yields. In addition, the reaction conditions are suitable to scale up and also exhibited high regioselectivity.