Dose-response associations between accelerometry measured physical activity and sedentary time and all cause mortality

摘要

Study question What is the magnitude and shape of dose-response associations between accelerometer assessed intensities of physical activity and sedentary time and all cause mortality? Methods This systematic review and harmonised meta-analysis was carried out on prospective cohort studies that measured physical activity and sedentary time by accelerometry. Individual level participant data were harmonised and analysed at study level. Sedentary time, total physical activity, and intensity specific physical activity were categorised by quarters (least active or least sedentary as referent) of physical activity intensity at study level, and Cox proportional hazards regression analyses were used to study specific associations with all cause mortality. Study results were summarised using random effects meta-analysis. Individual level data from eight studies (n=36 383, mean age 62.6 years), with median follow-up of 5.8 years (range 3.0-14.5 years) and 2149 (5.9%) deaths were analysed.