Amidooxime-Based Mononuclear Mn(II) Complexes: Synthesis, Characterization, and Studies on DNA Binding and Nuclease Activity

摘要

A number of new amidooxime based manganese(II) complexes have been synthesized and characterized by single crystal X-ray diffraction studies as well as by geometry optimization of complex 2 using DFT/B3LYP. All four complexes (1-4) are mononuclear having octahedral geometry. DNA binding interaction and nuclease activity of these compounds were investigated for diverse biomedical applications. The results of photophysical studies indicated that the Mn(II) compounds bind with DNA by intercalation mode and the complex 1 containing pyrimidine moiety and chloro ligation showed highest binding affinity. The binding affinities of these compounds were of the order of 10~4-10~5 M~(-1) and all of them were found to be capable of inducing DNA cleavage.