Zinc-Catalyzed Etherification Reaction of Aryl Iodides with Phenols

摘要

A novel and efficient Zinc-catalyzed C-O cross-coupling reaction have been developed using phenols with activated iodoarenes to afford diaryl ether derivatives in moderate to good yields under moderate reaction conditions. The reaction proceeds through an in situ generated Zn/L-proline complex. The use of relatively nontoxic and ecofriendly Zn, cheap and easily available amino acid ligand L-proline makes a better alternative for the synthesis of diaryl ethers. The main advantage of our protocol is that we could activate a d~(10) metal for the cross-coupling reaction. The scope and limitations of this protocol are also investigated.