An Asymmetric Synthesis of ((3R,6R)-6-Methylpiperidine-3-yl)methanol; A Piperidine Core Unit of Potent Dual Orexin Receptor Antagonist MK-6096

摘要

An asymmetric synthesis of ((3R,6R)-6-methylpiperidin-3-yl) methanol 2, a potent dual orexin receptor antagonist MK-6096 1 piperidine core unit, is described. The synthesis utilizes commercial available (S)-propylene oxide as a starting material and organocatalyzed asymmetric Michael addition reaction as key step.