(NH4)2S2O8-Mediated Direct Oxysulfonyloxylation of Alkynes with Sulfonic Acids to Access α-Sulfonyloxyketones

摘要

A novel method for the preparation of a-sulfonyloxyketones via a (NH4)2S2O8-mediated direct oxysulfonyloxylation of alkynes with sulfonic acids is described. This simple yet powerful method allows access to a variety of a-sulfonyloxyketones with a broad substrate scope. Furthermore, under the stipulated conditions, this methodology demonstrates excellent regioselectivity for some 1,2-disubstituted internal alkyne substrates, affording the corresponding a-sulfonyloxyketones in good yields.