Synergistic Catalysis of Ag(I)and Organo-N-heterocyclic Carbenes: One-Pot Synthesis of New Anticancer Spirooxindole-1,4-dihydropyridines

摘要

Ag(I)/organo-NHC catalyst pair(Lewis acidic/basic)delivered from labile Ag(I)-NHC complex in ethanol has shown synergistic effect to catalyze the one-pot four-component reaction of isatins,malononitrile,cyclic ketones and ammonium acetate to produce new series of spirooxindole-1,4-dihydropyridine scaffolds.Carbene trapping from pre-synthesized Ag(I)-NHC in the form of zwitterionic CS2-NHC adduct in ethanol provides evidence for the proposed synergistic catalysis.Besides,preliminary results of anticancer activity of these new spirooxindole-1,4-dihydropyridines are also presented.