Aza-Michael Addition of 5-Substituted Tetrazole Catalysed By a Novel Nanoparticle Solid Base Catalyst Involving a Layered Zinc Hydroxide Supported on a Ferrite Core

摘要

Fe3O4@SiO2@layered Zinc hydroxide(LZH)(0.85 mol%)efficiently was catalyzed the aza-Michael reaction of 5-substituted tetrazoles derivatives with α,β-unsaturated carbonyl compound under reflux in acetonitrile to produce the new compounds.These new compounds were investigated for antibacterial activity and studied for the structural properties by theoretical calculations.