Decorated Peptide Nanofibers with Cu Nanoparticles: An Efficient Catalyst for the Multicomponent Synthesis of Chromeno [2,3-d] pyrimidin-8-amines,Quinazolines and 2H-Indazoles

摘要

An efficient,simple and green protocol has been developed for the synthesis of 7,10-diaryl-7Hbenzo [7,8] chromeno[2,3-d] pyrimidin-8-amine,2H-indazole and quinazoline derivatives in the presence of decorated peptide nanofibers with Cu nanoparticles.Peptide nanofibre has been synthesised by selfassembly technique.In this work,the effect of succinic anhydride was evaluated in two conditions: i)without adding succinic anhydride at pH 4,ii)by adding succinic anhydride at pH 5.Synthesized peptide nanofiber was characterized by ~1H,~(13)C,DEPTNMR spectroscopies(Distortionless enhancement by polarization transfer),CHNSO,scanning electron microscopy(SEM),fluorescence spectroscopy,UV/Vis,FTIR and transmission electron microscopy(TEM).