Sustainable and Eco-Friendly Method for the Synthesis of Some Bioactive Derivatives of Biscoumarin and Pyrano [3,2-c]Chromene-3-Carbonitrile Using Taurine, as the Catalyst

摘要

Coumarin is a bio-organic compound which exists in some plants. Coumarin by its own or its derivatives are important compounds in the medicinal chemistry, agrochemistry fra- grance and food chemistry. Bis(4-hydroxycoumarin) derivatives are the most famous species of these compounds. Also, pyrano [3,2-c]chromene-3-carbonitrile derivatives which contain a moi- ety of 4-hydroxycoumarin have a wide range of biological activities. Taurine, the semi-essential β-amino acid in the organs of living creatures especially human and animals, is used as a green bio-organic catalyst to promote the formation of biscoumarin and pyrano[3,2-c]chromene-3-carbonitrile deriva- tives via a Knoevenagel-Micheal reaction in aqueous media. Using this method, the requested products are obtained in high yields during acceptable reaction times and the catalyst can be recycled with high efficiency. In fact, in this study, a bio- organic reagent is used as the catalyst to promote the synthesis of bioactive compounds in the greenest conditions possible.