Rapid, Simple and Efficient Microwave-Assisted Alkylation of 6-Acetyl-2H-Benzo[e][1, 3] Oxazine-2, 4(3H)-Dione

摘要

A simple, efficient and eco-friendly method has been devel- oped for the synthesis of biologically active alkyl derivatives of 6-acetyl-2H-benzo[e][1,3]oxazine-2,4(3H)-dione by using micro- wave irradiations. The N-alkylation of 6-acetyl-2H-benzo[e][1,3] oxazine-2,4(3H)-dione with substituted alkyl derivatives under microwave radiations in presence of Tetra-n-butyl ammonium bromide as a phase transfer catalyst to give the desired products. Comparison between conventional and microwave- assisted synthesis revealed that it reduced the reaction time, improve the yield and purity of 6-acetyl-3-(substituted alkyl)- 2H-benzo[e][1,3]oxazine-2,4(3H)-diones analog molecules. All the final compounds were characterized by FT-IR, 1 HNMR, 13 CNMR, HRMS and Mass spectroscopic analysis, also succeeded to develop and analyze the single crystal XRD of compound 4f. The antimicrobial evaluation studies show moderate activities against used microbes.