Dppf-Ligated Palladium Complex as an Efficient Catalyst for the Synthesis of Biaryl Ketones Using Co2(CO)8 as a C1 Source with High TON and TOF

摘要

In this reports, we have synthesized and characterized the palladium catalyst [Pd2(dppf)2(SC12H8S)]2(OTf)4 which is success- fully applied for Carbonylative Suzuki-Miyaura cross-coupling reaction. Synthesized catalyst was characterized by various analytical techniques such as 1 H NMR, 31 P NMR, CHNS, and single crystal X-ray diffraction. The use of Co2(CO)8 as a C1 source instead of gaseous CO is an additional advantage of the developed protocol. The current protocol showing excellent catalytic activity at ppm level of “Pd” concentration to provided high TON and TON. TON could be achieved up to 104 and TOF up to 103 . The protocol could tolerate a variety of functional groups and provided wide substrate scope including Heteroaryl ketones. The practical applicability of the proposed protocol up to gram level with marginal loss of the yield of the product. Remarkably, we have synthesized (4-methoxyphenyl) (3,4,5- trimethoxyphenyl)methanone and oxybenzone which is phar- maceutically active drug molecules under co-catalyst, and additive free condition. .