Metal-free Efficient Method for the Synthesis of N-(2-haloethyl)benzamides through the Ring-opening of2-oxazolines

摘要

An efficient, metal-free C-H halogenated method for the synthesis of β-halogenated carboxamides using non-corrosive NXS (X=Cl, Br) as the halogenated source and ammonium sulfocyanide (NH4SCN) as the additive was proposed and accomplished. Various substituted 2-oxazolines efficiently af- forded the corresponding β-halogenated carboxamides via a ring-opening reaction in good yields. The characteristic features of this reaction include readily available materials, mild reaction conditions and functional groups tolerance.