Synthesis, Antimicrobial and Antioxidant Activities of Pyrimidinyl Benzothiazine Carboxamides

摘要

A variety of pyrimidinyl benzothiazine carboxamides were prepared from benzothiazine carboxylate and 4,6-diaryl/hetero- arylpyrimidinyl-2-amines. The compounds having 4-nitro phenyl, 4-pyridinyl and pyrazolyl - pyrimidinyl benzothiazine carboxamide moieties 6e, 6i, 6j, 6k and 6m displayed prominent antibacterial activity against Bacillus subtilis. Further, compounds having pyrrolyl, pyrazolyl, pyridinyl and indolyl units 6f, 6k, 6m and 6n displayed prominent antifungal activity against Aspergillus niger. On the other hand, com- pounds with electron donating substituents on the aromatic ring (6b, 6c) and those with furan moiety (6g, 6h and 6l) displayed very good free radical scavenging activity greater than Ascorbic acid.