Mild and Efficient Synthesis of Functionalized Carbazoles via a DBU-Assisted Sequence Involving Cu- and Pd-Catalyzed Coupling Reactions

摘要

Practical access to diversely functionalized carbazoles has been developed by consecutive Cu-catalyzed Chan-Lam N-rylation of various o-iodoanilines and boronic acids, and Pd-catalyzed intramolecular aryl C-H activation of 2-iodo-N-arylanilines. Use of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as base was found beneficial for both steps.