Cascade Reactions Utilizing the Nucleophilic Properties of 1,1-Enediamines for the Regioselective Synthesis of 4-Aryl-2-aminopyridines

摘要

The novel 4-aryl-2-aminopyridine compounds 3 have been synthesised via the regioselective cascade reaction of 1,1-enediamines(EDAMs)1 with(E)-ethyl 2-oxo-4-phenylbut-3-enoates 2 in EtOH promoted by piperidine.The reactions have the advantages of using an environmen tally friendly solvent and inexpensive starting compounds to produce good to moderate yield.This method provides a concise procedure for the highly regioselective synthesis of 4-aryl-2-aminopyridine compounds.