Synthesis of New Quinazolin-4-(3H)-one Derivatives and Evaluation of Their Biological Activities

摘要

A new series of quinazolin-4-ones are conveniently synthesized in a one-pot procedure from anthranilamide derivatives and aldehydes using p-toluenesulfonic acid as a catalyst.The aim of inserting azo pyridyl and 4-amino benzamide groups in the structure of quinazolin-4-one derivatives is to achieve skeletal appearance with more antibacterial and antifungal properties.Therefore,the biological activities of the synthetic compounds were studied.The results revealed that almost all compounds exhibit antimicrobial activities.