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>Solvent-Free Synthesis and In Vitro Antitumor Activity of a New Class of (Z)-3-Arylidene-1H-pyrano[3,4-b]quinolin- 4(3H)-ones
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Solvent-Free Synthesis and In Vitro Antitumor Activity of a New Class of (Z)-3-Arylidene-1H-pyrano[3,4-b]quinolin- 4(3H)-ones
In the present investigation, an efficient and green synthesis of an intriguing array of structurally novel quinoline-based α- arylidene cycloketones i. e., (Z)-3-arylidene/ferrocenylmeth- ylene-5-methyl/phenyl-1H-pyrano[3,4-b]quinolin-4(3H)-ones (6a-z, 6aa and 6ab) has been successfully accomplished involving solvent-free reaction between pyrano[3,4-b]quinolin- 4(3H)-ones (7a-b) and various aromatic aldehydes by simple hand-grinding in a mortar and pestle using KOH as base at room temperature. The synthetic strategy has the attractive features such as experimental simplicity, mild and environ- mentally benign reaction conditions, easy work-up procedure and good yields.
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