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>Synthesis and Binding Affinity of Hydrophobic Tail Containing Naphthalene Derivatives with Different Type of Organized Media
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Synthesis and Binding Affinity of Hydrophobic Tail Containing Naphthalene Derivatives with Different Type of Organized Media
In this article, we are introducing the synthesis of two naphthalene derivatives (NPBU (butyl 2-(naphthalene-2-yl) acetate) and NPME (methyl 2-(naphthalene-2-yl)acetate)) hav- ing different length of aliphatic tail. These two newly synthe- sized naphthalene derivative are used as a fluorophore to understand the binding interaction with surfactants (SDS (sodium dodecyl sulfate), CTAB (cetrimonium bromide) and Triton X-100) and also with β-CD (β-cyclodextrin). Because of long hydrophobic tail, NPBU is more hydrophobic in nature and showed self-aggregation properties in aqueous medium. Whereas, the short aliphatic tail containing NPME not showed any self-aggregation property in an aqueous medium. Because of hydrophobicity NPBU could binds with the hydrophobic inner core of micelles of SDS, CTSB and Triton X-100. NPBU also formed inclusion complex with inner hydrophobic cavity of β- CD. However, because of low hydrophobicity NPME, could not able to binds with hydrophobic inner core of micelles and also it was not able to bind with hydrophobic cavity of β-CD. The calculated CMC (critical micelle concentration) values of SDS, CTAB and Triton X-100 by using NPBU fluorophore are ~12 mM, ~0.8 mM and ~0.12 mM respectively.
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