A “Turn-On” Fluorescence Probe for Selective Detection of Al 3+ in Aqueous Environment: Crystal Structure, Theoretical and Cell Imaging Studies

摘要

A furan-based water soluble fluorescent probe (E)-N’-(2,4- dihydroxybenzylidene)furan-2-carbohydrazide (DBF) has been synthesized and characterized by 1 HNMR, 13 CNMR, ESI-mass spectroscopy and single crystal X-ray diffraction techniques. The synthesized probe exhibits a “turn-on” fluorescence response towards Al 3+ in Tris-HCl buffer (10 mM) with no significant interference from other metal ions. The strong fluorescence in the presence of Al 3+ is attributed to the CHEF (chelation enhanced fluorescence), inhibition of PET (photo- induced electron transfer) and C=N isomerization.