Greener and Additive-Free Ring Opening of Epoxides by All-in-One Choline Systems

摘要

Adaptation of all-in-one ionic systems with ionic liquids(ILs)serving as solvent,reactant,and catalyst is an innovative approach in the organic synthesis.Mild and bio clean choline based ILs as all-in-one systems(solvent,reagent,and catalyst)were developed via a simple metathesis approach and were applied on the ring-opening reaction of epoxides.Sustained transformation of various epoxides using choline cyanide,azide,and hydroxide ILs delivered a neat,efficient and convenient protocol for the synthesis of β-substituted alcohols in moderate to high yields(64-97%)with excellent activity and selectivity as confirmed by nuclear magnetic resonance(NMR)spectroscopic data.