Highly efficient direct large-scale stoichiometric aldol reactions catalyzed by a new diamine salt in the presence of water

摘要

A new type of primary-tertiary diamine salt prepared can be used as a catalyst for direct aldol reaction and can display high yields, diastereoselectivities (up to 99:1), and enantiomeric excesses (up to 98%), by using stoichiometric amounts of cyclic ketones and various aryl aldehydes in the presence of water. This new catalyst can also be efficiently applied in large-scale reactions with the enantioselectivity being maintained at the same level, which indicates the potential for applications in industry.