Palladium-Catalyzed Cascade Carbonylative Cyclization Reaction of Trifluoroacetimidoyl Chlorides and 2-Iodoanilines: Toward 2-(Trifluoromethyl)quinazolin-4(3H)-ones Synthesis

摘要

A palladium-catalyzed cascade carbonylative/cyclization reac-tion for the synthesis of 2-(trifluoromethyl)quinazolin-4(3H)-ones has been achieved. The transformation utilizes readily available 2-iodoanilines and trifluoroacetimidoyl chlorides as the starting reagents, enabling a simple and convenient access to pharmaceutically significant quinazolin-4(3H)-one deriva-tives.