Two Routes for the Synthesis of Phosphorothioates via P-S Coupling Reaction of Dialkyl Phosphites with Thiols or a Mixture of Alkyl Halides and Thiourea in the Presence of CaO

摘要

In this report,two routes for the synthesis of phosphorothioates via a P-S cross coupling reaction of thiols with dialkyl phosphites or a three component reaction of alkyl halides,thiourea and dialkyl phosphite in the presence of CaO has been studied.By presented methods,various phosphorothioates are obtained under transition metal-free condition.The reactions are proceeded with formation of a known intermediate of disulfide via the oxidation of thiols and followed by nucleophilic substitution of dialkyl phosphite with the disulfide intermediate gave phosphorothioate.