In Vitro Antioxidant and Insulin Mimetic Activities of Heteroleptic Oxovanadium(IV)Complexes with Thiosemicarbazones and Naproxen

摘要

Six heteroleptic oxovanadium(IV)complexes with general formula [VOL~(1-6)(nap)],where,L~(1-3)=2-(1-(4-substitutedphenyl)ethylidene)hydrazinecarbothioamide,L~(4-6)=2-(1-(4-substitutedphenyl)ethylidene)-N-methylhydrazinecarbothioamide and nap=naproxen,have been synthesized and characterized.FTIR spectra exhibit a strong band between 965 and 991 cm~(-1),characteristic of υ(V=O)stretching vibration.UV-Vis and theoretical studies suggested distorted square-pyramidal geometry and oxidation state of vanadium(IV)with d1 configuration was confirmed by EPR spectra.Cyclic voltammograms exhibit metal based irreversible redox peaks corresponding to one electron oxidation(+0.83 to +0.70 V)and reduction(-0.69 to-0.53 V)processes.In vitro antioxidant studies revealed that complexes containing electron donating substituent(-CH3)showed higher activity.In vitro antidiabetic activity of complexes with enzymes like α-amylase,α-glucosidase and glucose-6-phosphatase made them better inhibitors of insulin,which is further supported by in silico studies,and complex 6 shows better in vitro insulin mimic activity against insulin responsive 3T3-L1 adipocyte cells compared to insulin and metformin.