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>A Facile One-Pot Synthesis of 1,2,3,4-Tetrahydroisoquinoline-1-carbonitriles via the Electrogenerated Cyanide Anions from Acetonitrile
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A Facile One-Pot Synthesis of 1,2,3,4-Tetrahydroisoquinoline-1-carbonitriles via the Electrogenerated Cyanide Anions from Acetonitrile
The electrosynthesis of 1,2,3,4-tetrahydroisoquinoline-1-carbon-itriles by acetonitrile reduction is a green and safe strategy to replace the traditional cyanation. Herein, we have obtained the 1,2,3,4-tetrahydroisoquinoline-1-carbonitrile in good yields by a simple reaction between dihydroisoquinolin-2-ium iodide and the electrogenerated acetonitrile formed under low temperature conditions, when a solution of dry acetonitrile is electro-lyzed at a Carbon rod as cathode and a magnesium plate as anode in undivided cell.
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